By the end of this course, students should be able to model, analyze, and design the following aspects of bioprocesses:

• The rates of enzyme-mediated reactions, including the influence of mass transfer.
• The stoichiometry and rates of cell metabolism and cell-mediated product formation.
• The rates of cell growth and product formation in batch, fed-batch, and continuous bioreactors.
• The importance of mixing and aeration considerations in bioreactor scale-up or scale-down.
• The throughput and yield of specific product recovery operations.

• Basic Microbiology and Biochemistry
• Enzymes and Biocatalysis
• Cell Metabolism and Bioenergetics
• Cell Culture and Bioreactors
• Oxygen Mass Transport and Bioreactor Scale-up/-down
• Separation Processes and Product Recovery
• Special Topics (animal cell culture, disposable, process analytical technology)

Shuler, M.L. and Kargi, F. Bioprocess Engineering: Basic Concepts, Second edition. Prentice Hall, 2002. ISBN 0-13-081908-5.

• Approximately 2 weekly homework sets. Completed homework must be turned on the due date. 20% deduction for late homework (up to 3 days overdue). Homework more than 3 days overdue will not be graded.
  
• Two (2) open-book mid-term exams. Students may take exams early or take make-up exams only with a certified medical excuse or prior approval of the instructor.
  
• Literature review on a topic in biochemical engineering (e.g., basic research, process design, process scale-up, optimization, etc.).

NCSU has recommended minimum specifications for computers used for classes. Depending on your computer needs, we recommend your computer meet or exceed the following minimum specifications below.

PCs must have an Intel-compatible 800 MHz processor, 256 MB RAM, 8 GB hard drive with 1 GB free space available, 256 Color Display, CD-ROM drive, 800x600 (min.) video adapter, sound card, and speakers. The operating system should be Windows 2000 or XP. Real One Player Basic (available free online) and high speed Internet connection such as cable, DSL, T1 or LAN will be required for EOL courses.

MAC users must have a G3 processor with firewire and USB factory built-in, 256 MB RAM, 10 GB with 1GB free space available, 256 Color Display, CD-ROM drive, 800x600 (min) video adapter, sound card, and speakers. The operating system must be MacOS 10.3 (minimum) along with the above RealOne and Internet specifications above .

For more detailed information on computer specifications and recommendations, please refer to our website at: http://engineeringonline.ncsu.edu/currentstudents/computeraccess.htm

Dr. H. Henry Lamb, Professor
Dept. of Chemical and Biomolecular Engineering
North Carolina State University
Engineering Building 1
Campus Box 7905
Raleigh , NC 27695-7905